A Lung-Parenchyma-Contrast Hybrid Network For Egfr Gene Mutation Prediction In Lung Cancer

Epidermal growth factor receptor (EGFR) mutation status is critical for lung cancer treatment planning. Current identification of EGFR mutation status relies on invasive biopsy and expensive gene sequencing. Recent studies revealed that CT images combined with deep learning can be used to non-invasively predict EGFR mutation status. However, how to enable the network focus on lung parenchyma area and extract discriminative features need further exploration. In this study, we proposed a lung-parenchyma-contrast (LPC) hybrid network that: 1) uses a fully automatic whole-lung analysis manner and enables the model focus on lung parenchyma area; 2) extracts local and global lung parenchyma features by contrastive learning strategy, and 3) jointly performs feature learning and classifier learning to improve predictive performance. We evaluated our network on a large multi-center dataset (2316 patients), which outperforms (AUC=0.827) the previous state-of-the-art methods. Extensive experiments also demonstrated the effectiveness of the contrastive learning modules.